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BRS Biochemistry, Molecular Biology and Genetics 6th Edition

BRS Biochemistry, Molecular Biology and Genetics 6th Edition pdf

BRS Biochemistry, Molecular Biology and Genetics 6th Edition pdf


BRS Biochemistry, Molecular Biology and Genetics 6th Edition pdf

BRS Biochemistry, Molecular Biology and Genetics 6th Edition pdf free download

BRS Biochemistry, Molecular Biology and Genetics 6th Edition ebook

Table of Contents:

1. Fuel Metabolism and Nutrition: Basic Principles 1

I. Metabolic Fuels and Dietary Components 1

II. The Fed or Absorptive State 5

III. Fasting 7

IV. Prolonged Fasting (Starvation) 9

Review Test 11

2. Ba sic Aspects of Biochemistry: Organic Chemistry,

Acid–Base Chemistry, Amino Acids, Protein

Structure and Function, and Enzyme Kinetics 19

I. A Brief Review of Organic Chemistry 19

II. Acids, Bases, and Buffers 20

III. Amino Acids and Peptide Bonds 22

IV. Protein Structure 25

V. Enzymes 34

Review Test 39

3. G ene Expression (Transcription), Synthesis of

Proteins (Translation), and Regulation of Gene

Expression 51

I. Nucleic Acid Structure 52

II. Synthesis of DNA (Replication) 58

III. Synthesis of RNA (Transcription) 66

IV. Protein Synthesis (Translation of mRNA) 70

V. Regulation of Protein Synthesis 77

VI. Recombinant DNA and Medicine 86

Review Test 95

4. C ell Biology, Signal Transduction, and

the Molecular Biology of Cancer 109

I. Compartmentation in Cells; Cell Biology and Biochemistry 110

II. Cell Signaling by Chemical Messengers 116

III. The Molecular Biology of Cancer 125

IV. Cancer and Apoptosis 131

V. Cancer Requires Multiple Mutations 133

VI. Viruses and Human Cancer 133

Review Test 134

5. G eneration of ATP from Metabolic Fuels and

Oxygen Toxicity 145

I. Bioenergetics 145

II. Properties of Adenosine Triphosphate 147

III. Electron Carriers and Vitamins 148

IV. TCA Cycle 154

V. Electron Transport Chain and Oxidative Phosphorylation 159

VI. Oxygen Toxicity and Free-Radical Injury 164

Review Test 170

6. Car bohydrate Metabolism 181

I. Carbohydrate Structure 181

II. Proteoglycans, Glycoproteins, and Glycolipids 185

III. Digestion of Carbohydrates 188

IV. Glycogen Structure and Metabolism 190

V. Glycolysis 197

VI. Gluconeogenesis 204

VII. Fructose and Galactose Metabolism 209

VIII. Pentose Phosphate Pathway 212

IX. Maintenance of Blood Glucose Levels 215

Review Test 220

7. Lipid and Ethanol Metabolism 230

I. Lipid Structure 232

II. Membranes 234

III. Digestion of Dietary Triacylglycerol 235

IV. Fatty Acid and Triacylglycerol Synthesis 237

V. Formation of Triacylglycerol Stores in Adipose Tissue 242

VI. Cholesterol and Bile Salt Metabolism 243

VII. Blood Lipoproteins 246

VIII. Fate of Adipose Triacylglycerols 251

IX. Fatty Acid Oxidation 252

X. Ketone Body Synthesis and Utilization 257

XI. Phospholipid and Sphingolipid Metabolism 259

XII. Metabolism of the Eicosanoids 262

XIII. Ethanol Metabolism 264

Review Test 268

8. N itrogen Metabolism–Amino Acids, Purines,

Pyrimidines, and Products Derived from

Amino Acids 279

I. Protein Digestion and Amino Acid Absorption 280

II. Addition and Removal of Amino Acid Nitrogen 282

III. Urea Cycle 284

IV. Synthesis and Degradation of Amino Acids 286

V. Interrelationships of Various Tissues in Amino Acid Metabolism 294

VI. Tetrahydrofolate, Vitamin B12, and S-Adenosylmethionine 298

VII. Special Products Derived from Amino Acids 302

Review Test 313

9. Molecular Endocrinology and An Overview of

Tissue Metabolism 325

I. Synthesis of Hormones 325

II. General Mechanisms of Hormone Action (Only a Summary is

Provided here as this has Already

Been Covered in Chapter 4.) 329

III. Regulation of Hormone Levels 329

IV. Actions of Specific Hormones 330

V. Biochemical Functions of Tissues 339

Review Test 350

10. H uman Genetics—An Introduction 359

I. Mendelian Inheritance Patterns 360

II. Genes 360

III. Mutations 361

IV. Inheritance Patterns 362

V. A Summary of Inheritance Patterns is given in Table 10.1. 367

VI. Cytogenetics 367

VII. Population Genetics 372

VIII. Multifactorial Diseases (Complex Traits) 372

IX. Triplet Repeat Expansions 373

X. Imprinting 374

XI. The Genetics of Tumor Suppressors 376

Review Test 378

Comprehensive Examination 389

Index 431

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